Abstract
| Enhanced Glucose-6-Phosphate Dehydrogenase Activities in Krill Oil Treated Female Wistar Rats Attenuated Adenine-Induced Cardio-In?ammatory Markers |
| Adewumi O. Oyabambi , Blessing B. Aindero , Winnifred O. Lord |
| Background: Adenine is a nucleotide found in diet of fowls, cow lungs, and kidneys of animals with a capacity for deleterious cardiovascular tissue damage. Krill oil is a major omega-3 containing supplement with huge health benecial effects. This study determines the role of Krill oil in adenine-induced cardiac toxicity of female Wistar rats. Materials and Method: Twenty female Wistar rats weighing between 120±5g were distributed into 4 groups; Control (CTR), Krill oil (Kh) (3% of diet), Adenine (18mg/kg), and Kh (3% of diet) + Adenine (18mg/kg bw orally). After six weeks, animals were anesthetized by chloroform inhalation and blood collected by cardiac puncture. Plasma and cardiac homogenate were analyzed and data expressed as mean ± SEM; p< 0.05 were accepted as signicant. Results: Krill oil increased plasma and tissue glucose-6-phosphate dehydrogenase (G6PDH), Nicotinamide adenine dinucleodtide phosphate (NADPH), Glutathione (GSH) and Glutathione peroxidase (GPx) in normal and Adenine-treated rats and decreased Interleukin 1- beta (IL-β), tumor necrosis factoralpha (TNF-α), Uric acid (UA) and C reactive protein (CRP). Adenine increased IL-β, TNF-α and CRP when compared with control and Krill oil reduced signicantly in both control and the adenine treated group. Conclusion: The study indicates that Adenine promotes cardiac tissue injury by increasing inammatory markers and Krill oil elicited a double fold increase in intracellular redox potential and lowering inammatory cardiac risk markers. |
| 10.47838/acem.26011977.127132022.asmeda.3.4 |
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